{"id":5678,"date":"2022-11-14T14:59:37","date_gmt":"2022-11-14T12:59:37","guid":{"rendered":"https:\/\/wordpress-759507-4181889.cloudwaysapps.com\/?page_id=5678"},"modified":"2025-01-24T18:25:31","modified_gmt":"2025-01-24T16:25:31","slug":"our-technology","status":"publish","type":"page","link":"https:\/\/chemotech.se\/staging\/?page_id=5678","title":{"rendered":"Our Technology"},"content":{"rendered":"\t\t
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Our Technology<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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ChemoTech have developed a new patented treatment technology platform called TSE – <\/span>Tumour Specific Electroporation\u2122<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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TSE - The Dynamic Electroporation Technology\n\n\u200b<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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TSE is a groundbreaking advancement in cancer treatment, developed following an in-depth evaluation of many ablative and destructive oncology therapies including the older static electroporation. Leveraging robust clinical evidence supporting electroporation\u2019s efficacy in treating malignant tumours, ChemoTech has pioneered the first dynamic electroporation technology. This innovation helps the treating physician avoid high and destructive currents, offering a safer and more precise treatment with limited damage to healthy tissue. Protected by multiple patents, TSE represents a unique and in some ways revolutionary approach in oncology using a patented CE-marked system for treating tumours.<\/p>

Furthermore, our quality management system is certified according to ISO 13485:2016 Medical devices \u2013 Quality management systems \u2013 Requirements for regulatory purposes.\u00a0<\/p>

Adapting and calibrating the technology, to be powerful enough to treat the tumour without generating destruction and ablation of healthy tissue is central to the TSE technology.<\/p>

Read more about our patents<\/a><\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Reducing Cell Destruction\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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TSE is designed to minimize the severe necrosis typically caused by traditional ablation and static electroporation methods. Instead of inducing rapid tissue breakdowns, TSE promotes apoptosis (programmed cell death), while sparing healthy surrounding tissue. This approach has been successfully used to treat hundreds of patients with cancers of the skin, head and neck, breast, bone, and pancreas, including cases unresponsive to standard therapies.<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Tailored Electric Fields for Optimal Treatment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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TSE\u2019s effectiveness lies in its patented innovation that adapts the electric field to the specific characteristics of each tumour. Excessively strong fields, which can cause ablation and necrosis by permanently destroying the cell\u2019s membrane, including cells in healthy tissue, are avoided. Instead, TSE is designed to optimize the reversible electroporation (mode of action), allowing cancer drugs to penetrate tumour cells effectively and establish the wanted apoptosis by breaking down the DNA before the cells can be diverted into new cells. This precision minimizes damage to healthy tissue while maximizing therapeutic outcomes.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In the case of an excessively strong electric field, heat ablation occurs, which means that even healthy tissue dies (necrotic destruction). Slightly lower strength (orange in the graph) also leads to necrotic destruction, which can be used for smaller tumours. Reversible electroporation – green – in in the graph is the goal of the treatment).<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Case Study with IQwave\u2122<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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In 2016, a case series involving 23 patients treated with IQwave\u2122 demonstrated the safety, efficacy, and future potential of TSE. The study included patients with breast cancer, head and neck cancer, and rare sarcomas, all of whom responded favourably. Unlike earlier technologies, TSE provides even distribution of the electrical field, minimizing necrosis and avoiding damage to healthy tissue while promoting apoptotic tumour cell death and immune modulation.<\/p>\n

Kalavathy Gurusamy et al. Trends in Cancer Research Vol 13, 2018:29-41<\/h6>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Ongoing Clinical Research<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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An investigator-initiated clinical study is ongoing at the All India Institute of Medical Sciences (AIIMS) in Jodhpur, India, to further evaluate the immunological mechanisms of cell death due to TSE in head- and neck cancer. Apart from including efficacy endpoints (according to state-of-the-art RECIST 1.1<\/span>), the study will provide insights into possible TSE-based combinatorial approaches to the treatment of solid cancers.\u00a0<\/span><\/p>

A clinical case series for pancreatic cancer is also ongoing at Ulis Medical Centre (Ulis MC) in Zaporizhia, Ukraine, with promising clinical outcomes in preliminary assessments. <\/span><\/strong><\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Kalavathy Gurusamy et al. Trends in Cancer Research Vol 13, 2018:29-41,
Esienhauer New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1), European Journal of Cancer, 45,2009, 228-247<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Advancing Electroporation with Innovation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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ChemoTech\u2019s patented technology enables multidimensional electroporation, allowing electrodes to be inserted at various angles to reach tumours up to 15 cm deep. This flexibility reduces the risk of overtreatment or undertreatment and avoids critical structures such as blood vessels and bones. This innovation paves the way for new indications, including stereotactic treatments and minimally invasive procedures for deeper tumours.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Research and Development Focus<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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ChemoTech remains committed to advancing TSE through continued R&D efforts, for both curative and later palliative stages of treatments. Our extended target for TSE includes addressing the more deep-seated tumours, such as pancreatic, liver and prostate cancer, with minimally invasive techniques such as laparoscopic or robotic approaches.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Collaborations and Global Reach<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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ChemoTech actively collaborates with oncologists, researchers, and medical institutions worldwide to refine and expand TSE\u2019s applications. Partnerships with leading cancer centres in India and other regions support early proof-of-concept studies and accelerate clinical adoption.\u00a0<\/p>

ChemoTech\u2019s Animal Care business area offers a versatile platform for advancing and refining our innovative products and treatments.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Manufacturing Excellence<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The IQwave\u2122 system is manufactured to the highest quality standards, ensuring reliability and accessibility for healthcare providers globally. ChemoTech\u2019s distribution networks are designed to bring TSE to patients and practitioners worldwide, solidifying its role as a leader in innovative cancer therapies.<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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R&D-project D-EEPC<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0(Dynamic-ElectroEnhanced Pain Control\u2122)<\/p>

Scandinavian ChemoTech AB has a short, animated video that explains its next R&D project D-EEPC (Dynamic-ElectroEnhanced Pain Control\u2122). This project can potentially become a revolutionary treatment for treating pain for patients with secondary bone cancer, especially located in the spine.<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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The four phases of TSE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Phase 1 \u2013\u00a0
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When using electroporation to enhance the effects of cytostatic the therapy begins by administering cytotoxic drugs to the patient. <\/p>

Cytostatic, such as Bleomycin, are inefficient outside the tumour cells, which is why the full effect of the cytostatic drug can only be achieved when combined with electroporation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Phase 2 \u2013
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By treating the tumour cell with TSE the cell membrane becomes reversibly permeable (formation of small pores and the ability to pass through substances), which allows the cytostatic to penetrate the cell nucleus. <\/p>

By increasing the permeability, considerably lower doses of cytostatic are required to achieve a therapeutic effect. The low dose of cytostatic significantly lowers the risk of side effects.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Phase 3 \u2013 Cytostatic enclosed in the tumour cell<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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After each treatment cycle with TSE, the cells reverse to a none-permeable state. This means that the cytostatic molecules become trapped inside the tumour cell.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Phase 4 \u2013 Cell death and immunological effect<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The three significant effects of this therapy are:<\/p>

  1. The cell\u2019s DNA is broken down by the cytostatic<\/li>
  2. The capillaries coagulate, which makes the cells starve and die<\/li>
  3. The activation of the immune system<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Our Technology ChemoTech have developed a new patented treatment technology platform called TSE – Tumour Specific Electroporation\u2122 TSE – The Dynamic Electroporation Technology \u200b TSE is a groundbreaking advancement in cancer treatment, developed following an in-depth evaluation of many ablative and destructive oncology therapies including the older static electroporation. Leveraging robust clinical evidence supporting electroporation\u2019s […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-5678","page","type-page","status-publish","hentry"],"yoast_head":"\nOur Technology - ChemoTech[Staging]<\/title>\n<meta name=\"description\" content=\"ChemoTech have developed a new patented treatment technology platform called TSE \u2013 Tumour Specific Electroporation\u2122.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Our Technology - ChemoTech[Staging]\" \/>\n<meta property=\"og:description\" content=\"ChemoTech have developed a new patented treatment technology platform called TSE \u2013 Tumour Specific Electroporation\u2122.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/chemotech.se\/staging\/?page_id=5678\" \/>\n<meta property=\"og:site_name\" content=\"ChemoTech[Staging]\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-24T16:25:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wordpress-759507-4181889.cloudwaysapps.com\/wp-content\/uploads\/2024\/12\/Phase_4-apoptos-1024x576.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/chemotech.se\\\/staging\\\/?page_id=5678\",\"url\":\"https:\\\/\\\/chemotech.se\\\/staging\\\/?page_id=5678\",\"name\":\"Our Technology - 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